Free imaging tumor response to therapy pdf download the first drugs for cancer chemotherapy became available more than 50 years ago at that time these chemotherapeutic agents were observed to produce tumor shrinkage and thus in some cases increased survival and even patient cure. Cancer is a major human health problem and a completely effective therapy is not available for most types of cancer the expected benefit of the treatment is assessed in terms of a reduction in both the size of the tumor and dissemination of the cancer imaging is an ideal tool with which to evaluate response. Optical imaging predicts tumor response to anti egfr therapy in the present study we demonstrate that antibody internalization may be used to determine response to cetuximab therapy tumor cell lines that had less internalization of labeled antibody in vitro had a greater response to cetuximab treatment in tumor xenografts in vivo. Introduction to date the main focus for innovations in imaging has been the achievement of excellence in anatomic resolution application of morphologic imaging to the evaluation of tumor response to treatment has led to the emergence of response criteria such as those proposed by the world health organization and the response evaluation criteria in solid tumors . Measurement of solid tumor response to treatment relies mainly on imaging who tumor response criteria and more recently recist response evaluation criteria in solid tumors have provided means to objectively measure tumor response in clinical trials with imaging
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